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BRCA and Beyond: The Genetics of Inherited Cancers
Our DNA weaves a complex genetic code. All cancers arise from aberrations, either somatic (acquired, not inherited) or germline (ancestral echoes, present from conception). Germline mutations, like in BRCA1/2, don't guarantee cancer but can predispose individuals to it. While most cancers are sporadic, nearly 10% have germline causes. These pathogenic mutations are heritable warning bells, illuminating heightened cancer risk not just for one person, but for future generations
aneeshhiremath3
May 142 min read
Democratising Cancer Prevention with Germline Testing
A seamstress's tale of familial tragedy led Dr. Warthin to study 'Family G,' later identified as Lynch Syndrome. This sorrowful start became a beacon of hope. Decades on, Dr. King's research unveiled BRCA1's link to breast cancer. Angelina Jolie's public BRCA1 journey then sparked the 'Angelina Jolie effect,' massively increasing awareness of genetic testing for hereditary cancers, highlighting its role in personalized healthcare decisions and empowering individuals to unders
aneeshhiremath3
May 142 min read
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